Anticonvulsants should not be discontinued abruptly because of the possibility of increasing seizure frequency; therapy should be withdrawn gradually to minimize the potential of increased seizure frequency, unless safety concerns require a more rapid withdrawal.

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In chronic therapy, phenytoin should be withdrawn gradually over 2 to 6 months or gradually transitioned to another antiepileptic agent to minimize the potential of increased seizure frequency, unless safety concerns require a more rapid withdrawal (Schachter 2020b).

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phenytoin and valproate may be tapered over a few days to zero, carbamazepine, lamotrigine and vigabatrin over 2-3 weeks and clonazepam, clobazam and primidone over weeks to months. It may take many years or even impossible to taper phenobarbitone to zero.

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