In neonates not responding to the standard used levetiracetam doses, incremental increases to 80-100 mg/kg/day may be considered.

Ref:
Hnaini, M., Darwich, M., Koleilat, N., Jaafar, F., Hanneyan, S., Rahal, S., El Mikati, I., Shbarou, R.M., Nabout, R., Maalouf, F.I. and Obeid, M., 2020. High-dose levetiracetam for neonatal seizures: a retrospective review. Seizure, 82, pp.7-11.