Perfelgan IV

First of all it’s not an absolute contraindication. Use with caution. Limited, low-dose therapy is usually well-tolerated in hepatic disease/cirrhosis; however, cases of hepatotoxicity at daily acetaminophen dosages <4,000 mg/day have been reported. Avoid chronic use in hepatic impairment.

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IV paracetamol leads to rapid and higher plasma levels than oral forms.

In severe liver disease, the liver’s capacity to metabolize the drug is impaired — increasing the risk of hepatotoxicity even at therapeutic doses.