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Solved181 viewsDrug Doses and Indications

What is the maximum recommended duration for using mannitol in the management of elevated intracranial pressure (ICP)? Additionally, should monitoring be limited to CT imaging, or are there alternative methods for assessing treatment efficacy and guiding therapy?

And max duration for dexa in ttt cerebral edema

Hossam Elgnainy Selected answer as best February 7, 2025
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Mannitol should be used only for a short duration (typically no longer than 24 to 48 hours) in the management of elevated ICP.

Monitoring of ICP and treatment response should employ continuous, bedside modalities (invasive ICP monitoring, ultrasound‐based techniques, and regular neurological exams) rather than relying solely on periodic CT scans.

In pediatric patients with cerebral edema, dexamethasone therapy dose, route, and duration may vary due to underlying cause of edema; tapering may be required.

But, is generally limited to a course of less than 14 days to minimize steroid‐related side effects.

For example, these are dosing regimens for dexamethasone:

Hossam Elgnainy Selected answer as best February 7, 2025