Some indications of mannitol requires certain concentrations. For example, Elevated Intraocular Pressure requires 1.5 to 2 g/kg of a 20% w/v solution or as a 15% w/v solution.

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Also, infusion rate is dependent upon indication:

Acute renal failure: Administer over 2 to 6 hours.

Cerebral edema or increased intracranial pressure: Administer over 20 to 30 minutes.

Test dose (for oliguria): Administer over 3 to 5 minutes.