Vitamin K1:

Route of administration varies with indication; careful evaluation of route of administration is important. The oral route is preferred in the treatment of nonbleeding patients with warfarin-associated coagulopathy; SubQ administration has fallen out of favor for this indication due to erratic and unpredictable absorption (Crowther 2002; DeZee 2006; Raj 1999). The IV route may be used in select nonbleeding patients and should be used in patients with major bleeding due to warfarin-associated coagulopathy (ACCP [Monagle 2012]; Bolton-Maggs 2002). The IV and SubQ routes may be used in the treatment of vitamin K deficiency bleeding (Kliegman 2020). The IM route should be avoided due to the risk of hematoma formation except in the prevention/treatment of vitamin K deficiency bleeding (Bolton-Maggs 2002; Eichenwald 2017; Kliegman 2020). Dosing presented in mcg and mg; verify dosing units.