Dose and indication of neubilized hypertonic salin 3%
Hossam Elgnainy Selected answer as best March 22, 2024
Hypertonic Saline 3% is indicated for Bronchiolitis, viral (mild to moderate, inpatient) and Cystic Fibrosis for Infants and children: the dose is 4 ml
every 2 hrs. for 3 doses.
Then every 4 hrs. for 5 doses.
Then every 6 hrs.
Other trials using doses of 2 to 4 mL every 6 hours have shown no benefit.
Hossam Elgnainy Selected answer as best March 22, 2024
– Kuzik BA, Al-Qadhi SA, Kent S, et al. Nebulized Hypertonic Saline in the Treatment of Viral Bronchiolitis in Infants. J Pediatr. 2007;151(3):266-270, 270.e1. [PubMed 17719935]
– Everard ML, Hind D, Ugonna K, et al. SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis. Thorax. 2014;69(12):1105-1112. [PubMed 25389139]
– Flores P, Mendes AL, Neto AS. A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants. Pediatr Pulmonol. 2016;51(4):418-425 [PubMed 26334188]
– Morikawa Y, Miura M, Furuhata MY, et al. Nebulized hypertonic saline in infants hospitalized with moderately severe bronchiolitis due to RSV infection: A multicenter randomized controlled trial. Pediatr Pulmonol. 2018;53(3):358-365. [PubMed 29327810]
– Silver AH, Esteban-Cruciani N, Azzarone G, et al. 3% Hypertonic Saline Versus Normal Saline in Inpatient Bronchiolitis: A Randomized Controlled Trial. Pediatrics. 2015;136(6):1036-1043. doi:10.1542/peds.2015-1037 [PubMed 26553190]