Hepatitis A

Antihistaminic Drugs for Children with Hepatitis A Virus (HAV) Infection:

1. General Considerations:
– Hepatitis A is a viral infection that does not typically cause allergic reactions, so antihistamines are generally not indicated for its treatment.
– If a child with HAV presents with allergic symptoms, antihistamines might be considered, but with caution due to potential liver impairment.

2. Recommended Antihistamines:
– Cetirizine and Loratadine: These second-generation antihistamines are generally safe for children but are contraindicated in severe hepatic impairment. Close monitoring is essential if used in children with liver involvement from HAV.

3. Alternatives:
– First-generation antihistamines like diphenhydramine should be used with caution due to anticholinergic side effects and potential drowsiness.

4. References:
– British National Formulary for Children
– American Academy of Allergy, Asthma & Immunology (AAAAI) guidelines
– European Academy of Allergy and Clinical Immunology (EAACI) recommendations

…

HAV Vaccination Post-Infection:

1. Post-Infection Vaccination:
– Individuals who have had HAV develop lifelong immunity, so vaccination is not necessary after infection.

2. Vaccination for Prevention:
– The HAV vaccine is recommended for susceptible individuals to prevent infection, not for treatment post-infection.

3. References:
– Centers for Disease Control and Prevention (CDC) guidelines on HAV vaccination