Because of the life-threatening and complex nature of this condition, management must be carried out in an intensive care unit at a liver transplant center. Treatment of acute liver failure is supportive; the definitive lifesaving therapy is liver transplantation. Supportive measures are listed in this Table . Efforts are made to treat metabolic derangements, avoid hypoglycemia, support respiration, minimize hepatic encephalopathy, and support renal function.

Ref: Nelson Essentials of pediatrics 2023 9th EDition.