75 units/kg IV over 10 minutes, followed by 28 units/kg per hour continuous infusion. Four hours after initiating therapy, measure aPTT, then adjust dose to achieve an aPTT that corresponds to an anti-factor Xa level of 0.35 to 0.7 (this is usually equivalent to an aPTT of 60 to 85 seconds). Treatment should be limited to 10 to 14 days. Some experts recommend switching to low molecular weight heparin after 3 to 5 days. For renal vein thrombosis requiring treatment, 6 weeks to 3 months of heparin/low molecular weight heparin therapy is recommended.

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Administer IV loading doses over 10 minutes. Administer maintenance infusion by continuous IV infusion in compatible solution (various concentrations may be used). The concentrations are typically from 100 units/mL to 500 units/mL for loading doses and 10 to 500 units/mL for continuous IV infusion.