Heparin dose for cvl in pediatric

For cvl patency as heparin it depends on concentration rather than dose , range from 10 iu/ml upto 100 iu/ml in pediatric.

Only on neonate it can be used as infusion with rate at 0.5 to 1 iu/kg l/hr for line patency For preparation First determine lumin size for example 3 ml Second define desirable concentration for example 10 iu/ml Third define ampoule concentration which is almost 5000 iu/ml Fourth make serial dilutions to take desired 30 iu ( dilute 5000 iu inn50 ml NS it will make 100 iu/ml then take 0.3 ml dilute to 3 ml ns )and dilute upto 3 ml with normal saline and lock it in each port for minimum 8 hours