Idiopathic short stature (ISS): Note: Guidelines recommend against the routine use of somatropin in every child with HtSDS ≤−2.25; decision to use should be made on a case-by-case basis (PES [Grimberg 2016]).

Children and Adolescents:

Guideline recommendations: SubQ: Initial dose: 0.24 mg/kg weekly divided into equal doses 6 to 7 days/week. Individualize dose based on patient response; some patients may require up to 0.47 mg/kg weekly in divided doses (PES [Grimberg 2016]).