1. Ascites with low albumin levels: There’s limited information for infants, children, and adolescents. Administer 25% albumin intravenously at a dose of 1 g/kg over 2 to 3 hours, repeatable up to three times daily until albumin levels exceed 2.5 g/dL. Maximum dose per administration: 25 g (Giefer 2011, Sabri 2003).

2. Hypovolemia and plasma volume expansion, including hypovolemic shock (SCCM [Dellinger 2013]): For infants, children, and adolescents, administer 5% albumin intravenously at a dose of 0.5 to 1 g/kg (10 to 20 mL/kg) over 5 to 10 minutes. Standard adult dose: 12.5 to 25 g (250 to 500 mL) per administration. Repeat if needed after 30 minutes (Kleigman 2007).

3. Large volume paracentesis: Limited data for infants, children, and adolescents. Administer 5% or 25% albumin intravenously at a dose of 0.5 to 1 g/kg over 1 to 2 hours after the procedure (Giefer 2011, Kramer 2001).

4. Edema refractory to treatment in nephrotic syndrome: For infants, children, and adolescents, administer 25% albumin intravenously at a dose of 0.5 to 1 g/kg over 30 to 60 minutes, followed by diuretic therapy (Gipson 2009; Kliegman 2011; Robinson 2003).