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Is there a significant role for dexamethasone in road traffic accident?

Hossam Elgnainy Answered question May 14, 2025
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in the pediatric setting, dexamethasone does not play a significant routine role in the acute management of children involved in road traffic accidents (RTAs):

1. Pediatric Traumatic Brain Injury (TBI):

  • Dexamethasone is not recommended.
  • Similar to adults, corticosteroids (including dexamethasone) have shown no benefit in improving outcomes in pediatric TBI.
  • They may actually increase risks such as hyperglycemia, infections, and gastrointestinal bleeding.
  • Guidelines like those from the Brain Trauma Foundation advise against steroid use in pediatric TBI.

2. Spinal Cord Injury:

  • No clear evidence supports dexamethasone or any steroid in pediatric spinal cord trauma.
  • Corticosteroids are generally not recommended, especially in the first 24–48 hours, due to risk of complications and lack of proven benefit.

3. Airway Edema / Facial Trauma:

  • In cases of upper airway swelling (e.g., after maxillofacial trauma, intubation, or crush injuries to the neck), dexamethasone may be used to reduce edema and risk of obstruction.
  • This is not routine but can be life-saving in selected cases.

4. Adrenal Insufficiency / Chronic Steroid Use:

  • If a child with known adrenal insufficiency or on chronic corticosteroids is involved in an RTA, stress-dose steroids (including IV dexamethasone) may be indicated to prevent adrenal crisis.

5. Anti-Emetic Use (supportive care):

  • Rarely, dexamethasone is used as an antiemetic in trauma-related nausea/vomiting, but not a common practice in pediatric emergency trauma care.

In short:

Dexamethasone has a limited and selective role in pediatric RTAs. It is not used routinely for head injury, spinal trauma, or general trauma support. Its use is reserved for:

  • Managing airway edema
  • Children with adrenal insufficiency
  • Rare supportive scenarios (e.g., severe inflammation, antiemesis)
Hossam Elgnainy Edited answer May 14, 2025