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Is there synergistic effect between cephalosporin and penicillin groups of antibiotics, and cover what spectrum?
Hossam Elgnainy Selected answer as best January 25, 2025
The role of synergistic effect of double beta lactam regimens is very limited to certain situations such as the regimen used in MDR Acinetobacter infections (colistin+meropenem+ampicillin/sulbactam) or the salvage double carbapenem therapy used to be prescribed for MDR Klebsiella (meropenem+ertapenem). Other than some invitro studies, there is no strong evidence to support the use of double beta lactam regimens in most situations.
Hossam Elgnainy Selected answer as best January 25, 2025
It’s worth mentioning that in cases of Infective Endocarditis:
If the patient has a beta-lactam or gentamicin-susceptible strain of enterococci, they should be treated with a beta-lactam (e.g., amoxicillin, ampicillin) plus ceftriaxone for 6 weeks or gentamicin for 2 weeks.
The combination of ampicillin or amoxicillin plus ceftriaxone for 6 weeks may also be used if the patient has an Enterococcus faecalis strain with high-level aminoglycoside resistance, although this treatment is not active against Enterococcus faecium.
https://doi.org/10.1093/eurheartj/ehad193