can levofloxacin 750mg be crushed ? How can it be diluted in 5ml or 15 ml or 30 ml water ? With source please
**Pt is switched from iv levofloxacin and not lined br ryle
Levofloxacin is not really soluble in water. Crushing it with water will not be of any use.
Levofloxacin can be extemporaneously prepared as suspension:
A 50 mg/mL oral suspension may be made with tablets and a 1:1 mixture of Ora-Plus® and strawberry syrup NF. Crush six 500 mg levofloxacin tablets in a mortar and reduce to a fine powder. Add small portions of the vehicle and mix to a uniform paste; mix while adding the vehicle in incremental proportions to almost 60 mL; transfer to a graduated cylinder, rinse mortar with vehicle, and add quantity of vehicle sufficient to make 60 mL. Label “shake well”. Stable for 57 days when stored in amber plastic prescription bottles at room temperature or refrigerated.
Ref:
- PubChem. Levofloxacin, pubchem.ncbi.nlm.nih.gov. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Levofloxacin#section=Solubility (Accessed: 6 February 2024).
- VandenBussche HL, Johnson CE, and Fontana EM, et al, “Stability of Levofloxacin in an Extemporaneously Compounded Oral Liquid,” Am J Health Syst Pharm, 1999, 56(22):2316-8.[PubMed 10582824]
I suggest to change levofloxacin to another agent, if levofloxacin oral suspension is not available.
