Administer as soon as possible and within 3 hours of injury.

The infusion given directly after the loading dose.

If the dose administration delayed more than 3 hours, there is no clear guide on that. I recommend to give the loading, also.

For patient wt=20kg:

1. Give 15mg/kg loading over 10 min:

Given the ampoules conc = 500mg/5ml

Let’s say dilute up to 50ml

Loading may be administered either undiluted or diluted in a compatible diluent “D5W or NS”

$$15 \times 20 \times \frac{50}{500} = 30 \text{ ml}$$

So loading of 30 ml administer over 10 min.

..

2. Mentainance infuse 2mg/kg/hr. For at least 8 hrs or untill the bleeding stops.

$$2 \times 20 \times \frac{50}{500} = 4 \text{ ml/hr}$$

So the rate of infusion is 4 ml/hr.