Baby on sominaletta but convulsions not control we need to add epanutine what should we do to avoid SE of these compination
Hossam Elgnainy Selected answer as best April 22, 2024
Concomitant use of phenobarbital (a CYP2C9/CYP2C19 inducer) with phenytoin (a CYP2C9/CYP2C19 substrate) may decrease phenytoin exposure, which may reduce the efficacy of phenytoin.
If concomitant use cannot be avoided, closely monitor neonates and consider increasing the phenytoin dosage accordingly (Prod Info SEZABY(TM) intravenous injection, 2022).
Concurrent phenobarbital and phenytoin therapy may increase, decrease, or cause no change in the serum levels of phenytoin (Hansten, 1974).
Hossam Elgnainy Selected answer as best April 22, 2024
