بِسْمِ اللَّـهِ الرَّحْمَـٰنِ الرَّحِيمِ الَّذِي خَلَقَنِي فَهُوَ يَهْدِينِ وَالَّذِي هُوَ يُطْعِمُنِي وَيَسْقِينِ وَإِذَا مَرِضْتُ فَهُوَ يَشْفِينِ
Solved2.17K viewsDrug Doses and Indications
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What are the dosing of Levosimendan in pediatrics?

Hossam Elgnainy Selected answer as best February 28, 2024
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No established dose in pediatrics.

The practically used doses are the doses of adults.

Hossam Elgnainy Edited answer March 1, 2024

Adult doseing:
Acute decompensated heart failure (ADHF): IV: Initial: 6 to 12 mcg/kg infused over 10 minutes. Maintenance: 0.1 mcg/kg/minute by continuous infusion. Note: ESC heart failure guidelines recommend against administration of initial bolus dose in patients with systolic BP <90 mm Hg (Ponikowski 2016).

Dosage adjustments with concomitant medication (initial dose): Concomitant IV vasodilator or inotropic agents: Reduce initial infusion dose to 6 mcg/kg over 10 minutes.

Dosage adjustments (maintenance infusion):

If significant hypotension or tachycardia occur: Decrease infusion rate to 0.05 mcg/kg/minute or discontinue.

If inadequate response: May increase infusion up to 0.2 mcg/kg/minute.

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