Dose:

Limited data available: Note: Reported regimens are variable and ideal dose-response is not established:

• Children <12 years: IV: Loading dose: 15 mg/kg over 10 minutes given within 3 hours of injury (maximum dose: 1,000 mg/dose), followed by continuous IV infusion at 2 mg/kg/hour for ≥8 hours or until bleeding stops (Beno 2014; Royal College of Pediatrics and Child Health 2012).
• Children ≥12 years and Adolescents: IV: Loading dose: 1,000 mg over 10 minutes given within 3 hours of injury, followed by 1,000 mg infused over 8 hours (Beno 2014; Royal College of Pediatrics and Child Health 2012).

.

Preparation:

Loading dose: May be further diluted in 1 mL/kg or 20 mL NS (Goobie 2011; Reid 1997; Schindler 2011).

IV infusion: Some experts recommend diluting in NS or D5W to a final concentration of 1 mg/mL (Royal College of Pediatrics and Child Health 2012).

.

Administration:

Intermittent IV dose: May be administered undiluted by direct IV injection at a maximum rate of 100 mg/minute; faster rates may cause hypotension.

Continuous IV infusion:

• Loading dose: May be administered either undiluted or diluted in a compatible diluent; infuse over 5 to 15 minutes (Beno 2014; Dadure 2011; Goobie 2011; Neilipovitz 2001; Reid 1997; Royal College of Pediatrics and Child Health 2012; Sethna 2005). Neonatal patients received loading doses over 60 minutes (Keijzer 2012).
• IV infusion: Following dilution, administer by continuous IV infusion at a rate not to exceed 100 mg/minute.