Administration over 2 to 4 minutes has been reported in pediatric patients >11 years and adults primarily in the outpatient setting (Baumgartner 1983; Garrelts 1988; Poole 1999) and over 5 minutes in pediatric patients ages newborn to 15 years with meningitis (Grubbauer 1990; Martin 1984).

Rapid IVP injection over 5 minutes of a 2,000 mg dose resulted in tachycardia, restlessness, diaphoresis, and palpitations in an adult patient (Lossos 1994).

IV push administration in young infants may also have been a contributing factor in risk of cardiopulmonary events occurring from interactions between ceftriaxone and calcium (Bradley 2009).