Give 40 mg/kg/dose at the recommended age-specific dosing interval

Less than 32 weeks GA and less than 14 days PNA: every 12 hours .

Less than 32 weeks GA and 14 days PNA and older: every 8 hours .

32 weeks GA and older: every 8 hours .

Reference:

Smith PB, Cohen-Wolkowiez M, Castro LM et al: Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatr Infect Dis J Oct, 2011; 30(10): 844-849.

van den Anker JN, Pokorna P, Kinzig-Schippers M et al: Meropenem pharmacokinetics in the newborn. Antimicrob Agents Chemother Sep, 2009; 53(9): 3871-3879.

Bradley JS, Sauberan JB, Ambrose PG et al: Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate. Pediatr Infect Dis J Sep, 2008; 27(9): 794-799.